Childhood Lead Exposure and Adult Neurodegenerative Disease
نویسندگان
چکیده
منابع مشابه
Lead exposure and neurodegenerative diseases
Lead (Pb) pollution has been considered as a major threat for human health. Lead may be able to induce inflammatory cascades in various tissues. Allergic asthma and neurodegenerative diseases inflammatory diseases that the association between lead exposure and occurrence of these problems has been proven. The aim of present review is to summarize literature on the effects of lead exposure and o...
متن کاملNeurodegenerative disease and adult neurogenesis.
The generation and cell death of newly generated cells have critical roles in brain development and maintenance in the embryonic and adult brain. Alterations in these processes are also seen in neurodegenerative diseases. Genes that are key players in neurodegenerative diseases (α-synuclein, presenilin-1, tau, huntingtin) are also physiologically involved in modulating brain plasticity. Interes...
متن کاملEnvironmental lead exposure during early childhood.
OBJECTIVE To determine the relative contribution of residential lead hazards to children's blood lead concentrations during early childhood. METHODS We enrolled children 6 months of age and followed them until 24 months of age. Blood and samples of dust, soil, water and paint were analyzed for lead at 6-month intervals, and interviews were conducted to estimate nutritional, behavioral, and de...
متن کاملSeasonal influences on childhood lead exposure.
We conducted a study to examine seasonal changes in residential dust lead content and its relationship to blood lead in preschool children. We collected blood and dust samples (floors, windowsills, and carpets) to assess lead exposure. The geometric mean blood lead concentrations are 10.77 and 7.66 microg/dL for the defined hot and cold periods, respectively (p < 0.05). Lead loading (milligrams...
متن کاملLow-level environmental lead exposure in childhood and adult intellectual function: a follow-up study
BACKGROUND Early life lead exposure might be a risk factor for neurocognitive impairment in adulthood. OBJECTIVES We sought to assess the relationship between early life environmental lead exposure and intellectual function in adulthood. We also attempted to identify which time period blood-lead concentrations are most predictive of adult outcome. METHODS We recruited adults in the Boston a...
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ژورنال
عنوان ژورنال: Journal of Alzheimer's Disease
سال: 2018
ISSN: 1387-2877,1875-8908
DOI: 10.3233/jad-180267